Still, there remains a lack of understanding about the risk factors leading to AKI after OLT. In the last decade, there have been many efforts to improve perioperative management and to enhance the use of intervention drugs with less nephrotoxicity. Deterioration in renal function in this setting is also associated with increased 30-day mortality rate, graft dysfunction and 1-year mortality. Despite the inaccuracy of creatinine as a marker for renal dysfunction in cirrhotic patients, it is still used as a gold standard for the diagnosis of AKI after OLT.ĪKI after OLT is a common complication, with incidences ranging from 12–95% –. However, although pre-procedure serum creatinine is a well recognized risk factor for Acute Kidney Injury (AKI) in many surgical scenarios, some studies do not confirm this correlation in liver transplanted patients. Renal dysfunction, measured by the pre-procedure serum creatinine, is a key component of that score. The MELD score for prioritizing organs for liver transplantation is calculated based on serum creatinine, the international normalized ratio (INR) and serum bilirubin. However, the role of the score in predicting complications after OLT has yet to be evaluated. MELD has been a useful tool to predict mortality for patients awaiting OLT. Understanding the prognosis of the cirrhotic patients awaiting orthotopic liver transplantation (OLT) and assessing morbid-mortality risk factors are critical points in the development of strategies to improve long-term outcomes and assist in planning public health strategies.įor over a decade, the Model for End-Stage Liver Disease (MELD) has been used worldwide as the criteria for organ allocation in patients with chronic liver disease.

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